ASYMMETRIC REDUCTIONS OF KETONES, IMINES, AND OXIMES USING BIOCATALYTIC ENZYMES FOUND IN PEA PLANTS Honors Research Thesis Presented in partial fulfillment of the requirements for graduation with honors research distinction in Chemistry in the undergraduate colleges of The Ohio State
نویسنده
چکیده
منابع مشابه
Reactions of Aldehydes and Ketones and their Derivatives
Formation and Reactions of Acetals and Related Species . . . . . . . . . . . . . . 1 Reactions of Glucosides and Nucleosides . . . . . . . . . . . . . . . . . . . . . . . . . 4 Reactions of Ketenes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Formation and Reactions of Nitrogen Derivatives . . . . . . . . . . . . . . . . . . . 7 Imines . . . . . . . . . . . . ...
متن کاملOrganocatalyzed oxidative N-annulation for diverse and polyfunctionalized pyridines.
This paper describes a novel strategy for the synthesis of 2,3,4-trisubstituted pyridines via organocatalyzed three-component reactions. A variety of pyridine derivatives are synthesized from readily available ketones with α,β-unsaturated aldehydes and ammonium acetate under a mild organocatalyst. This protocol leads to rapid N-annulation through C-C and C-N bond formation in a single operation...
متن کاملSynthesis of azaheterocycles from oxime derivatives*
Electrophilic amination of Grignard reagents has been accomplished by using O-sulfonyloximes as amination reagents. Benzophenone O-sulfonyloxime derivatives react with Grignard reagents on sp2 nitrogen, yielding primary amines by successive hydrolysis of the resulting N-alkylimines. Various cyclic imines are synthesized by Pd-catalyzed reaction from olefinic oxime derivatives. That is, treatmen...
متن کاملHydrolytic stability of hydrazones and oximes.
Molecules containing carbon–nitrogen double bonds are prevalent in both chemical and biological contexts. The foundations for our current understanding of carbon–nitrogen double-bond formation and hydrolysis were laid by seminal work on hydrazone hydrolysis and formation, and by contributions from mechanistic studies on enzymes that utilize pyridoxal phosphate. In particular, the meticulous kin...
متن کاملI2-SDS-H2O System: A highly Efficient Dual Catalytic Green System for Deprotection of Imines and in Situ Preparation of Bis(indolyl)alkanes from Indoles in Water
A novel catalytic system consisting of I2-SDS-H2O has been developed which cleaves 2,3-diaza-1,3-butadiene, 1-aza-1,3-butadienes, oximes and in presence of indoles in the medium uses the corresponding aldehyde products to produce bis(indolyl)alkanes in situ. This one pot simple and mild dual catalytic system works in water at room temperature under neutral conditions.
متن کامل